Kisan Thapa.

Projects

Selected work focusing on leveraging computational techniques for biological insight.

Screenshot of the CausalPath Webserver interface

CausalPath Webserver

Active

CausalPath analyzes molecular profiles (phosphoproteomics, transcriptomics, etc.) to infer causal biological mechanisms by integrating prior knowledge from pathway databases. It helps explain experimental observations in the context of known biology.

Tech: Java, JavaScript, HTML, CSS, Cytoscape.js
Diagram illustrating the Transcription Factor Activity Prediction project workflow

Cell Activity Inference Landscape (KALE)

Ongoing

This project implements rank-based methods (like GSEA, VIPER) within a webserver to predict transcription factor (TF) activity from gene expression data. It provides biologists with an accessible tool to infer regulatory changes.

Tech: Python, Flask, Pandas, NumPy